Description

(S)-1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a key precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and process development. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require enantiomerically pure intermediates for drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates, especially in neurological and oncological therapeutic areas.
• API Development: Serves as a key building block in the research and process chemistry stages of new Active Pharmaceutical Ingredient (API) development.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop novel bioactive molecules.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable synthetic routes for commercial pharmaceutical manufacturing.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs serving the global pharmaceutical industry.

Basic Information

Product Name	(S)-1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine Hydrochloride
CAS No.	346421-67-8
Molecular Formula	C10H14ClN3O4S
Molecular Weight	307.75 g/mol
Synonyms	(S)-1-(2-Nitrobenzenesulfonyl)pyrrolidin-3-amine hydrochloride; (3S)-1-[(2-Nitrophenyl)sulfonyl]-3-pyrrolidinamine hydrochloride; (S)-3-Amino-1-(2-nitrobenzenesulfonyl)pyrrolidine hydrochloride; (S)-1-(2-Nitrobenzenesulfonyl)-3-aminopyrrolidine HCl; (S)-N-(2-Nitrobenzenesulfonyl)-3-aminopyrrolidine hydrochloride; (S)-3-Amino-N-(2-nitrophenylsulfonyl)pyrrolidine hydrochloride; Pyrrolidin-3-amine, 1-[(2-nitrophenyl)sulfonyl]-, hydrochloride, (3S)-
EINECS	Contact for details

Quality Control

Our (S)-1-(2-Nitro-Benzenesulfonyl)-Pyrrolidin-3-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards typical for pharmaceutical intermediates, including identity confirmation, purity assay, and control of chiral purity and related substances. Certificates of Analysis (COA) detailing specific results for each lot are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.