Description

[2-(4,6-Dimethyl-Quinazolin-2-Ylamino)-5-Oxo-4,5-Dihydro-1H-Imidazol-4-Yl]-Acetic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and targeted drug discovery. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and new active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel quinazoline and imidazole-based drug candidates.
• Kinase Inhibitor Research: Used in the development of potential tyrosine kinase and protein kinase inhibitors for targeted cancer therapies.
• Medicinal Chemistry: A crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme interactions and cellular signaling pathways.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for creating complex molecules with specific biological activity.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and scale-up of advanced intermediates for clinical trials.

Basic Information

Product Name	[2-(4,6-Dimethyl-Quinazolin-2-Ylamino)-5-Oxo-4,5-Dihydro-1H-Imidazol-4-Yl]-Acetic Acid
CAS No.	345951-23-7
Molecular Formula	C₁₆H₁₇N₅O₃
Molecular Weight	327.34 g/mol
Synonyms	2-[(4,6-Dimethylquinazolin-2-yl)amino]-5-oxo-4,5-dihydro-1H-imidazol-4-ylacetic acid; 4-(Carboxymethyl)-2-[(4,6-dimethyl-2-quinazolinyl)amino]-4,5-dihydro-5-oxo-1H-imidazole; (2-((4,6-Dimethylquinazolin-2-yl)amino)-5-oxo-4,5-dihydro-1H-imidazol-4-yl)acetic acid; Quinazolin-imidazolone acetic acid derivative; CAS 345951-23-7
EINECS	Contact for details

Quality Control

Our [2-(4,6-Dimethyl-Quinazolin-2-Ylamino)-5-Oxo-4,5-Dihydro-1H-Imidazol-4-Yl]-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.