Description

1,4,8,11-Tetrakis(Dimethylaminocarbonylmethyl)-1,4,8,11-Tetraazacyclotetradecane is a sophisticated, multi-dentate macrocyclic ligand belonging to the cyclam family, functionalized with amide groups. This compound is valued for its strong and selective chelating properties, particularly for transition and lanthanide metal ions, enabling the formation of stable, well-defined complexes. It is a critical intermediate and reagent for researchers and manufacturers in advanced materials science, catalysis, and diagnostic imaging agent development.

Application

• MRI Contrast Agent Precursor: Serves as a key chelator for gadolinium (Gd³⁺) and other paramagnetic ions in the development of next-generation magnetic resonance imaging (MRI) contrast media.
• Catalysis & Homogeneous Catalysis: Used to synthesize highly active and selective metal complexes for organic transformations, polymerization, and oxidation reactions.
• Radiopharmaceuticals: Acts as a bifunctional chelating agent for radionuclides (e.g., Copper-64, Gallium-68) in positron emission tomography (PET) and targeted radiotherapy.
• Metal Ion Separation & Sensing: Employed in analytical chemistry for the selective extraction, separation, and fluorescent sensing of specific metal ions from complex matrices.
• Supramolecular Chemistry & Materials: A building block for constructing metal-organic frameworks (MOFs), molecular machines, and other functional supramolecular assemblies.
• Bioconjugation & Drug Delivery: Functionalized for attaching metal complexes to antibodies, peptides, or nanoparticles for targeted therapeutic and diagnostic applications.

Basic Information

Product Name	1,4,8,11-Tetrakis(Dimethylaminocarbonylmethyl)-1,4,8,11-Tetraazacyclotetradecane
CAS No.	345612-68-2
Molecular Formula	C₂₆H₅₂N₈O₄
Molecular Weight	540.76 g/mol
Synonyms	1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetramethylamide; Cyclam-tetraacetamide; TETRA; 1,4,8,11-Tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane; 1,4,8,11-Tetrakis(2-(dimethylamino)-2-oxoethyl)-1,4,8,11-tetraazacyclotetradecane; DO3A-tetramide; 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetamide
EINECS	Contact for details

Quality Control

Our production of 1,4,8,11-Tetrakis(Dimethylaminocarbonylmethyl)-1,4,8,11-Tetraazacyclotetradecane adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC purity assay, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.