Description

1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid, Tetrahydrochloride, Hydrate is a high-purity, functionalized macrocyclic chelating agent, essential for the synthesis of advanced diagnostic and therapeutic agents. Its core value lies in its exceptional ability to form stable, inert complexes with a wide range of metal ions, particularly lanthanides and transition metals. This makes it a critical intermediate for researchers and manufacturers in the pharmaceutical, medical imaging, and radiopharmaceutical industries who require reliable, high-quality building blocks for targeted molecular probes.

Application

• Synthesis of MRI Contrast Agents: Acts as a key precursor for gadolinium-based contrast agents used in magnetic resonance imaging (MRI) to enhance image clarity and diagnostic accuracy.
• Radiopharmaceutical Development: Serves as a bifunctional chelator for labeling peptides, antibodies, and other targeting molecules with radioactive isotopes (e.g., 68Ga, 177Lu, 64Cu) for positron emission tomography (PET) and targeted radionuclide therapy.
• Catalysis Research: Used to create well-defined metal complexes that serve as catalysts in organic synthesis and polymerization reactions.
• Chemical Sensing and Analysis: Employed in the development of luminescent probes and sensors for the detection of specific metal ions or biological analytes in research and diagnostic assays.
• Material Science: Utilized in the surface functionalization of nanoparticles and other materials to impart specific metal-binding properties for technological applications.

Basic Information

Product Name	1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid, Tetrahydrochloride, Hydrate
CAS No.	339091-75-7
Molecular Formula	C18H34Cl4N4O9 (anhydrous basis)
Molecular Weight	584.29 g/mol (anhydrous basis)
Synonyms	DOTA-tetrahydrochloride hydrate; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tetrahydrochloride hydrate (common misnomer); 2,2',2'',2'''-(1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetrayl)tetraacetic acid tetrahydrochloride hydrate; Tetraazacyclotetradecanetetraacetic acid tetrahydrochloride; Cyclam-tetraacetic acid tetrahydrochloride hydrate; DOTA•4HCl•xH2O; Macrocyclic chelator DOTA tetrahydrochloride.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for assay, impurity profile, and other critical parameters are available upon request. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 10.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Chloride Content	Conforms to theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.