Description

6-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-2-(Methylsulfanyl)[1,2,4]Triazolo[1,5-A]Pyrimidine is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound matters for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Research: Serves as a core structure for developing new generation pesticides and herbicides, leveraging the biological activity of the triazolopyrimidine moiety.
• Chemical Biology Probe: Used in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its specific heterocyclic architecture.
• Material Science: Potential application in the development of organic electronic materials and metal-organic frameworks (MOFs) as a functional ligand.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and kilogram-scale production under cGMP or non-GMP conditions for clinical trial material.

Basic Information

Item	Details
Product Name	6-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-2-(Methylsulfanyl)[1,2,4]Triazolo[1,5-A]Pyrimidine
CAS No.	338420-97-6
Molecular Formula	C12H5ClF3N4S
Molecular Weight	345.71 g/mol
Synonyms	6-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidine; 2-(Methylthio)-6-[3-chloro-5-(trifluoromethyl)-2-pyridyl][1,2,4]triazolo[1,5-a]pyrimidine; CAS 338420-97-6; 6-(3-Chloro-5-trifluoromethyl-2-pyridyl)-2-methylsulfanyl-[1,2,4]triazolo[1,5-a]pyrimidine; [1,2,4]Triazolo[1,5-a]pyrimidine, 6-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-2-(methylthio)-
EINECS	Contact for details

Quality Control

Our 6-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-2-(Methylsulfanyl)[1,2,4]Triazolo[1,5-A]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.