Description

5'-o-(Dimethoxytrityl)-N2-Ethyl-2'-Deoxyguanosine CAS NO 337380-92-4 is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block in the automated solid-phase synthesis of DNA and RNA sequences, where its protecting groups ensure precise and efficient chain elongation. It is primarily required by pharmaceutical R&D teams, biotechnology companies, and academic research institutions developing therapeutic oligonucleotides, diagnostic probes, and advanced molecular biology tools.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite precursor for manufacturing antisense oligonucleotides (ASOs), siRNA, and aptamers for targeted therapies.
• Research-Grade Primer & Probe Fabrication: Used in the custom synthesis of labeled and modified DNA probes for PCR, sequencing, and hybridization applications.
• Antisense Drug Development: Critical for creating modified DNA strands that regulate gene expression in drug discovery pipelines.
• Synthesis of Modified Nucleosides: Serves as an intermediate for further chemical modifications to study structure-activity relationships (SAR).
• Genomic Tool Development: Employed in creating specialized oligonucleotides for CRISPR guide RNAs and next-generation sequencing libraries.

Basic Information

Product Name	5'-o-(Dimethoxytrityl)-N2-Ethyl-2'-Deoxyguanosine
CAS No.	337380-92-4
Molecular Formula	C33H35N5O6
Molecular Weight	597.67 g/mol
Synonyms	5'-O-DMT-N2-Ethyl-2'-deoxyguanosine; N2-Ethyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine; DMT-N2-Et-dG; 2'-Deoxy-N2-ethyl-5'-O-(4,4'-dimethoxytrityl)guanosine; N2-Ethyl-2'-deoxy-5'-O-DMT-guanosine; 5'-O-(4,4'-Dimethoxytrityl)-N2-ethyl-2'-deoxyguanosine; Guanosine, 2'-deoxy-N2-ethyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-
EINECS	Contact for details

Quality Control

Our 5'-o-(Dimethoxytrityl)-N2-Ethyl-2'-Deoxyguanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, temperature-controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.