Description

2-(1-Amino-2-Methylpropyl)-3-Benzyl-7-Chloroquinazolin-4(3H)-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, or inflammatory diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities in academic and industrial R&D labs.
• API Synthesis: Used in the multi-step manufacturing process of complex target molecules, where its specific quinazolinone core is integral to the final drug's activity.
• Biochemical Tool Compound: May be utilized in biochemical assays and pharmacological studies to investigate specific enzyme inhibition or receptor modulation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for clinical trials.

Basic Information

Product Name	2-(1-Amino-2-Methylpropyl)-3-Benzyl-7-Chloroquinazolin-4(3H)-One
CAS No.	336119-88-1
Molecular Formula	C19H20ClN3O
Molecular Weight	341.84 g/mol
Synonyms	7-Chloro-2-(1-amino-2-methylpropyl)-3-benzyl-4(3H)-quinazolinone; 2-(1-Amino-2-methylpropyl)-3-benzyl-7-chloro-3,4-dihydroquinazolin-4-one; 3-Benzyl-7-chloro-2-(1-amino-2-methylpropyl)quinazolin-4(3H)-one; 336119-88-1; 7-Chloro-3-benzyl-2-(1-amino-2-methylpropyl)quinazolin-4(3H)-one; Quinazolin-4(3H)-one, 2-(1-amino-2-methylpropyl)-3-benzyl-7-chloro-
EINECS	Contact for details

Quality Control

Every batch of 2-(1-Amino-2-Methylpropyl)-3-Benzyl-7-Chloroquinazolin-4(3H)-One is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.