Description

(S)-1-Cyclohexyl-2,2,2-Trifluoroethan-1-Amine Hydrochloride CAS NO 336105-50-1 is a high-purity chiral amine hydrochloride salt, characterized by its cyclohexyl and trifluoromethyl substituents. This compound is a critical chiral building block for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its stereochemistry and fluorine content are essential for biological activity. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into peptide backbones to create analogs with improved stability and binding affinity.
• Fluorine Chemistry Building Block: Utilized in medicinal chemistry to introduce the trifluoromethyl group, a common bioisostere known to improve pharmacokinetic properties.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in regulatory and analytical laboratories.

Basic Information

Item	Detail
Product Name	(S)-1-Cyclohexyl-2,2,2-Trifluoroethan-1-Amine Hydrochloride
CAS No.	336105-50-1
Molecular Formula	C8H15F3N·HCl
Molecular Weight	221.66 g/mol
Synonyms	(S)-1-Cyclohexyl-2,2,2-trifluoroethylamine hydrochloride; (S)-α-(Trifluoromethyl)cyclohexanemethylamine hydrochloride; (S)-1-Cyclohexyl-2,2,2-trifluoroethanamine HCl; (1S)-2,2,2-Trifluoro-1-cyclohexylethanamine hydrochloride; (S)-1-Cyclohexyl-2,2,2-trifluoroethan-1-amine HCl; (S)-1-Cyclohexyl-2,2,2-trifluoroethylammonium chloride
EINECS	Contact for details

Quality Control

Our (S)-1-Cyclohexyl-2,2,2-Trifluoroethan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, chiral purity analysis, and NMR to ensure identity, potency, and purity meet exacting standards. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance in GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.