Description

(S)-1-(4-Chlorophenyl)-2,2,2-Trifluoroethylamine Hcl CAS NO 336105-42-1 is a high-purity chiral amine hydrochloride salt, characterized by a trifluoromethyl group and a chlorophenyl moiety, which are critical for imparting unique physicochemical properties. This compound serves as a valuable pharmaceutical intermediate and chiral building block in advanced organic synthesis. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and agrochemical sectors for the development of active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Building block for developing novel pesticides and herbicides, leveraging the biological activity of the trifluoromethyl and chlorophenyl groups.
• Asymmetric Catalysis: Used as a chiral ligand precursor or auxiliary in stereoselective synthesis to control the configuration of new chiral centers.
• Chemical Research: Employed in academic and industrial R&D for exploring structure-activity relationships (SAR) and novel fluorinated compounds.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	(S)-1-(4-Chlorophenyl)-2,2,2-Trifluoroethylamine Hydrochloride
CAS No.	336105-42-1
Molecular Formula	C8H8ClF3N·HCl
Molecular Weight	260.51 g/mol
Synonyms	(S)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanamine hydrochloride; (S)-α-(4-Chlorophenyl)-2,2,2-trifluoroethylamine HCl; (S)-4-Chloro-α-(trifluoromethyl)benzylamine hydrochloride; (1S)-1-(4-Chlorophenyl)-2,2,2-trifluoroethanaminium chloride; (S)-1-(p-Chlorophenyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-Trifluoromethyl(4-chlorophenyl)methylamine HCl; (S)-CF3-PCA HCl
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Chlorophenyl)-2,2,2-Trifluoroethylamine HCl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.