Description

Nh2-Et-Otbu Hcl is a high-purity chemical intermediate, specifically an amino acid derivative with a tert-butyl ester protecting group. This compound is critical for researchers and manufacturers requiring precise molecular building blocks for complex synthesis. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of peptide-based drugs and complex organic molecules targeting various therapeutic areas.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative to control reaction sequences.
• Protecting Group Chemistry: The tert-butyl ester (OtBu) group provides stability during synthesis and can be selectively removed under mild acidic conditions.
• Bioconjugation: Serves as a precursor for creating linkers or modifying biomolecules in drug delivery system development.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating custom molecular libraries.
• API Development: Integral to the research and scale-up process for new active pharmaceutical ingredients, particularly in oncology and metabolic disease research.

Basic Information

Item	Details
Product Name	Nh2-Et-Otbu Hcl
CAS No.	335598-67-9
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	2-Amino-2-ethylbutanoic acid tert-butyl ester hydrochloride; tert-Butyl 2-amino-2-ethylbutanoate hydrochloride; 2-Ethyl-2-aminobutanoic acid tert-butyl ester HCl; Aminoethyl-tert-butyl ester hydrochloride; (2-Amino-2-ethylbutyric acid)-O-t-butyl ester hydrochloride; AEEB-OtBu HCl; NH2-CH(C2H5)2-COOtBu HCl
EINECS	Contact for details

Quality Control

Our Nh2-Et-Otbu Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.