Description

Ethanone, 1-(2-Chloro-3-Pyridinyl)-2,2-Difluoro- (9Ci) is a high-purity fluorinated pyridinyl ketone building block, identified by CAS number 335449-20-2. This compound is valued for its unique molecular structure, which incorporates both chloro and difluoro functional groups, making it a versatile intermediate for advanced chemical synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the difluoro and chloropyridine motifs contribute to biological activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or precursor for synthesizing advanced polymers and functional materials with specific optical or electronic properties.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs) in academic and industrial research settings.
• Fluorine Chemistry Studies: An important reagent for investigating structure-activity relationships (SAR) and metabolic stability in medicinal chemistry programs due to its fluorinated structure.

Basic Information

Product Name	Ethanone, 1-(2-Chloro-3-Pyridinyl)-2,2-Difluoro- (9Ci)
CAS No.	335449-20-2
Molecular Formula	C7H4ClF2NO
Molecular Weight	191.56 g/mol
Synonyms	1-(2-Chloro-3-pyridinyl)-2,2-difluoroethanone; 2-Chloro-3-(2,2-difluoroacetyl)pyridine; 2,2-Difluoro-1-(2-chloro-3-pyridinyl)ethanone; 2-Chloro-3-pyridyl difluoromethyl ketone; 1-(2-Chloro-3-pyridinyl)-2,2-difluoroethan-1-one; (2-Chloro-3-pyridyl)-2,2-difluoroacetyl; Difluoro(2-chloro-3-pyridinyl)methanone
EINECS	Contact for details

Quality Control

Our production of Ethanone, 1-(2-Chloro-3-Pyridinyl)-2,2-Difluoro- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All batches are fully characterized and undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.