Description

1-Boc-2-(4-Nitrobenzenesulfonyl)Hydrazine is a high-purity, protected hydrazine derivative widely used as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its dual functionality, where the Boc (tert-butoxycarbonyl) group provides orthogonal protection for the hydrazine nitrogen, and the 4-nitrobenzenesulfonyl (Nosyl) group acts as a versatile activating and protecting group, enabling selective transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of complex heterocycles, active pharmaceutical ingredients (APIs), and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nitrogen-containing heterocycles, such as pyrazoles and indazoles, which are core structures in many drug candidates.
• Peptide Mimetics & Conjugate Chemistry: Used in the preparation of hydrazide-based peptide analogs and bioconjugates, leveraging the Nosyl group for selective deprotection.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides that incorporate hydrazine-based pharmacophores.
• Material Science Research: Serves as a precursor for functionalized polymers and dendrimers requiring precise nitrogen insertion.
• Cross-Coupling & Catalysis: Acts as a substrate in palladium-catalyzed cross-coupling reactions to construct complex carbon-nitrogen bonds.
• Academic & Process R&D: A valuable reagent for method development in organic synthesis, exploring new protection/deprotection strategies and reaction pathways.

Basic Information

Product Name	1-Boc-2-(4-Nitrobenzenesulfonyl)Hydrazine
CAS No.	333440-71-4
Molecular Formula	C11H15N3O6S
Molecular Weight	317.32 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-[(4-nitrophenyl)sulfonyl]hydrazine; tert-Butyl 2-((4-nitrophenyl)sulfonyl)hydrazine-1-carboxylate; Boc-Nosyl-hydrazine; 1-Boc-2-Nosyl-hydrazine; N-Boc-N'-nosylhydrazine; 2-((4-Nitrobenzenesulfonyl)hydrazinecarboxylic acid tert-butyl ester; (4-Nitrobenzenesulfonyl)hydrazine, N-Boc-protected; N-(tert-Butoxycarbonyl)-N'-(4-nitrobenzenesulfonyl)hydrazine
EINECS	Contact for details

Quality Control

Our 1-Boc-2-(4-Nitrobenzenesulfonyl)Hydrazine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and scale-up applications. We adhere to cGMP principles where applicable, and all products are supported by comprehensive analytical data. A Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity confirmation, and impurity profiles as determined by HPLC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.