Description

6-Chloro-1,2-Dihydro-2-Oxospiro[4H-3,1-Benzoxazine-4,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethyl Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. Its complex spirocyclic and heterocyclic architecture makes it a critical building block for the research and development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Employed in the process development and scale-up stages for new active pharmaceutical ingredients requiring its specific fused-ring structure.
• Chemical Synthesis: Acts as a versatile intermediate for further functionalization, enabling the creation of diverse chemical entities for biological screening.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	6-Chloro-1,2-Dihydro-2-Oxospiro[4H-3,1-Benzoxazine-4,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethyl Ethyl Ester
CAS No.	332187-61-8
Molecular Formula	C18H21ClN2O4
Molecular Weight	364.83 g/mol
Synonyms	tert-Butyl 6-chloro-2-oxo-1,2-dihydrospiro[4H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxylate; 6-Chloro-1,2-dihydro-2-oxospiro[4H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 6-Chloro-2-oxo-1,2-dihydrospiro[4H-3,1-benzoxazine-4,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[4H-3,1-benzoxazine-4,4'-piperidine] intermediate; BOC-protected spirocyclic benzoxazine piperidine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical specifications. We support development and commercial projects with GMP-compatible processes and documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.