Description

4-[(6-Bromo-4-Phenylquinazolin-2-Yl)Amino]Benzoic Acid is a high-purity, advanced pharmaceutical intermediate with a distinct quinazoline-benzoic acid hybrid structure. This compound matters for its critical role as a versatile building block in the research and development of targeted small-molecule therapeutics, particularly kinase inhibitors. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to synthesize novel drug candidates for oncology and other therapeutic areas, where its specific bromo and phenyl substitutions are key for modulating biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel quinazoline-based kinase inhibitors for oncology research.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Tool Compound: Employed in vitro to study enzyme inhibition mechanisms and cellular signaling pathways.
• Fine Chemical Synthesis: Acts as a specialized building block for creating complex heterocyclic compounds in custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for pioneering studies in organic synthesis and drug discovery methodologies.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the cGMP production of active pharmaceutical ingredients (APIs) in clinical trial materials.

Basic Information

Product Name	4-[(6-Bromo-4-Phenylquinazolin-2-Yl)Amino]Benzoic Acid
CAS No.	332102-08-6
Molecular Formula	C21H14BrN3O2
Molecular Weight	420.26 g/mol
Synonyms	4-[(6-Bromo-4-phenylquinazolin-2-yl)amino]benzoic acid; Benzoic acid, 4-[(6-bromo-4-phenyl-2-quinazolinyl)amino]-; 2-Quinazolinamine, 6-bromo-N-(4-carboxyphenyl)-4-phenyl-; 6-Bromo-N-(4-carboxyphenyl)-4-phenylquinazolin-2-amine; 4-(6-Bromo-4-phenylquinazolin-2-ylamino)benzoic acid; 332102-08-6; 4-(6-Bromo-4-phenyl-quinazolin-2-ylamino)-benzoic acid
EINECS	Contact for details

Quality Control

Our 4-[(6-Bromo-4-Phenylquinazolin-2-Yl)Amino]Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.