Description

(S)-3-Amino-4-(4-Trifluoromethylphenyl)-Butyric Acid-Hcl CAS NO 332061-82-2 is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its structural motif, which incorporates both a trifluoromethyl group and an amino acid backbone, making it a critical synthon in modern medicinal chemistry. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially those targeting neurological and psychiatric conditions.
• Protease Inhibitor Research: Used in the development of inhibitors for various enzymes, leveraging its amino acid-like structure.
• Peptidomimetics: Serves as a non-natural amino acid analog for constructing modified peptides with enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate for creating advanced crop protection agents with improved efficacy.
• Material Science: Can be utilized in the synthesis of specialized polymers and advanced organic materials.

Basic Information

Product Name	(S)-3-Amino-4-(4-Trifluoromethylphenyl)-Butyric Acid Hydrochloride
CAS No.	332061-82-2
Molecular Formula	C11H13F3NO2 • HCl
Molecular Weight	283.68 (Free base) / 320.14 (HCl salt)
Synonyms	(S)-3-Amino-4-(4-(trifluoromethyl)phenyl)butanoic acid hydrochloride; (S)-γ-Amino-4-(α,α,α-trifluoro-p-tolyl)butyric acid hydrochloride; (3S)-3-Amino-4-[4-(trifluoromethyl)phenyl]butanoic acid hydrochloride; (S)-ATPB HCl; 332061-82-2; (S)-3-Amino-4-(4-trifluoromethylphenyl)butyric acid HCl salt
EINECS	Contact for details

Quality Control

Our production of (S)-3-Amino-4-(4-Trifluoromethylphenyl)-Butyric Acid-Hcl adheres to stringent quality protocols suitable for pharmaceutical R&D. Every batch is characterized and tested to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and optical rotation analyses. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.