Description

(R)-3-Amino-4-(2-Trifluoromethylphenyl)-Butyric Acid-Hcl CAS NO 332061-78-6 is a high-purity chiral building block and advanced pharmaceutical intermediate. Its value lies in the critical trifluoromethylphenyl moiety and defined stereochemistry, which are essential for modulating the biological activity and metabolic stability of drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting protein-protein interactions.
• Protease Inhibitor Development: Used in research for constructing peptide-mimetic backbones for inhibitors of various proteases.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final structure of potential APIs, leveraging the trifluoromethyl group for enhanced lipophilicity and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective synthesis routes due to its defined (R)-configuration.

Basic Information

Product Name	(R)-3-Amino-4-(2-Trifluoromethylphenyl)-Butyric Acid Hydrochloride
CAS No.	332061-78-6
Molecular Formula	C11H13F3NO2 • HCl
Molecular Weight	283.68 (Free base) / 320.14 (HCl salt)
Synonyms	(R)-3-Amino-4-(2-trifluoromethylphenyl)butanoic acid hydrochloride; (R)-3-Amino-4-(α,α,α-trifluoro-o-tolyl)butyric acid HCl; (R)-ATPB HCl; (R)-3-Amino-4-(2-(trifluoromethyl)phenyl)butanoic acid hydrochloride; (R)-2-Trifluoromethylphenyl-β-amino butyric acid hydrochloride; (R)-3-Amino-4-(o-trifluoromethylphenyl)butyric acid hydrochloride; (3R)-3-Amino-4-[2-(trifluoromethyl)phenyl]butanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-Amino-4-(2-Trifluoromethylphenyl)-Butyric Acid-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.