Description

p-(3,4-Difluorophenylethynyl)Phenol is a high-purity, specialized organic intermediate featuring a phenol core linked to a difluorophenyl group via an ethynyl bridge. This unique molecular architecture makes it a valuable building block for synthesizing advanced materials and complex pharmaceutical compounds. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Building block for developing new-generation herbicides and fungicides with enhanced efficacy and selectivity.
• Liquid Crystal & OLED Materials: Serves as a core unit in the production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, improving thermal stability and electronic properties.
• Polymer Modification: Used to incorporate fluorinated aromatic units into high-performance polymers, enhancing their chemical resistance and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Academic & Industrial Research: Critical reagent in medicinal chemistry and material science research for exploring new chemical entities and functional materials.

Basic Information

Product Name	p-(3,4-Difluorophenylethynyl)Phenol
CAS No.	331718-48-0
Molecular Formula	C14H8F2O
Molecular Weight	230.21 g/mol
Synonyms	4-[(3,4-Difluorophenyl)ethynyl]phenol; 1-(3,4-Difluorophenyl)-2-(4-hydroxyphenyl)acetylene; Phenol, 4-[(3,4-difluorophenyl)ethynyl]-; p-(3,4-Difluorophenylethynyl)phenol; 331718-48-0; 4-(3,4-Difluorophenylethynyl)phenol; (4-((3,4-Difluorophenyl)ethynyl)phenol)
EINECS	Contact for details

Quality Control

Every batch of p-(3,4-Difluorophenylethynyl)Phenol is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS analysis, to ensure compliance with industry standards and precise customer specifications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.