Description

3-Bromoisatoic Anhydride is a specialized brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional reactivity, serving as a versatile precursor for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals. Its controlled reactivity profile makes it a critical reagent for introducing the isatoic anhydride scaffold with a halogen handle for further functionalization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of quinazolinone and quinoline-based drug candidates with potential anticancer, antimicrobial, or kinase inhibitory activity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Chemical Biology Probes: Utilized to create tagged or fluorescent derivatives for studying biological pathways and protein interactions.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	3-Bromoisatoic Anhydride
CAS No.	331646-98-1
Molecular Formula	C8H4BrNO3
Molecular Weight	242.03 g/mol
Synonyms	3-Bromo-1H-benzo[d][1,3]oxazine-2,4-dione; 3-Bromo-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione; 3-Bromo-1,3-dihydro-2H-3,1-benzoxazine-2,4-dione; 3-Bromoisatoic acid anhydride; Isatoic Anhydride, 3-bromo-; 3-Bromo-2H-3,1-benzoxazine-2,4(1H)-dione
EINECS	Contact for details

Quality Control

Our 3-Bromoisatoic Anhydride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.