Description

3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Ethoxy]Methyl]-6-Methyl-3,5-Pyridinedicarboxylate CAS NO 331258-36-7 is a high-purity, complex heterocyclic compound featuring a pyridine dicarboxylate core with a phthalimide-protected aminoethoxy side chain. This molecule is of significant commercial interest as a key pharmaceutical intermediate in the synthesis of advanced active pharmaceutical ingredients (APIs). It is primarily sought by research organizations and fine chemical manufacturers engaged in developing and scaling up novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry research and development.
• API Synthesis: Used in the production route for Active Pharmaceutical Ingredients (APIs) targeting specific therapeutic areas, leveraging its unique molecular scaffold.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for new chemical entities (NCEs) before commercial production.
• Contract Research & Manufacturing (CRAM): Supplied to CRAM organizations that require reliable, high-quality intermediates for client projects.
• Academic & Industrial Research: Utilized in chemical biology and drug discovery programs to explore new structure-activity relationships.

Basic Information

Product Name	3-Ethyl 5-Methyl 4-(2-Chlorophenyl)-2-[[2-(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Ethoxy]Methyl]-6-Methyl-3,5-Pyridinedicarboxylate
CAS No.	331258-36-7
Molecular Formula	C30H27ClN2O7
Molecular Weight	562.99 g/mol
Synonyms	1,3-Dihydro-2H-isoindole-2-acetic acid, 1,3-dioxo-, 2-[2-[[3-(2-chlorophenyl)-5-(ethoxycarbonyl)-4,6-dimethyl-2-pyridinyl]methoxy]ethyl] ester; 2-[2-[[3-(2-Chlorophenyl)-5-(ethoxycarbonyl)-4,6-dimethyl-2-pyridinyl]methoxy]ethyl] 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetate; 3-Ethyl 5-methyl 4-(2-chlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate; Phthalimide-protected pyridine dicarboxylate intermediate
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. All materials undergo comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay, related substances, and residual solvents. We support development and commercial projects requiring compliance with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.