Description

(S)-(-)-5,5',6,6'-Tetramethyl-3,3'-Di-tert-Butyl-1,1'-Biphenyl-2,2'-Diol is a high-value, chiral biphenol derivative widely recognized for its utility as a sophisticated ligand and building block in asymmetric synthesis. Its importance stems from its rigid, sterically hindered structure, which is crucial for inducing high enantioselectivity in catalytic reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric catalysis, including hydrogenation, oxidation, and C-C bond-forming reactions.
• Key precursor for synthesizing salens and other metal-complexing ligands used in enantioselective transformations.
• Building block for functional polymers and advanced materials requiring specific chiral environments.
• Intermediate in the research and development of pharmaceutical active ingredients (APIs) with defined stereochemistry.
• Component in the synthesis of agrochemicals, such as chiral pesticides and herbicides.
• Use in analytical chemistry as a chiral selector or resolving agent.

Basic Information

Product Name	(S)-(-)-5,5',6,6'-Tetramethyl-3,3'-Di-tert-Butyl-1,1'-Biphenyl-2,2'-Diol
CAS No.	329735-68-4
Molecular Formula	C28H42O2
Molecular Weight	410.64 g/mol
Synonyms	(S)-VAPOL; (S)-(-)-2,2'-Dihydroxy-3,3'-di-tert-butyl-5,5',6,6'-tetramethyl-1,1'-biphenyl; VAPOL ligand; (S)-5,5',6,6'-Tetramethyl-3,3'-bis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diol; (S)-(-)-5,5',6,6'-Tetramethyl-3,3'-di-tert-butylbiphenyl-2,2'-diol; (aS)-5,5',6,6'-Tetramethyl-3,3'-bis(1,1-dimethylethyl)[1,1'-biphenyl]-2,2'-diol
EINECS	Contact for details

Quality Control

Our (S)-(-)-5,5',6,6'-Tetramethyl-3,3'-Di-tert-Butyl-1,1'-Biphenyl-2,2'-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with research and development specifications. Certificates of Analysis (COA) detailing identity, purity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.