Description

cis-3'-Oxo-Spiro[Cyclohexane-1,1'(3'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and fused heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and complex generics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of target drug molecules, especially those with spirocyclic cores.
• Medicinal Chemistry Research: Used as a scaffold or building block in drug discovery programs for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Integral in the production route for active pharmaceutical ingredients targeting central nervous system (CNS) disorders, metabolic diseases, or other specialized therapeutic areas.
• Process Development & Scale-Up: Employed in process chemistry for route scouting, optimization, and pilot-scale manufacturing of candidate drugs.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects requiring high-purity, complex intermediates.
• Reference Standard: Can be utilized as an analytical reference standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	cis-3'-Oxo-Spiro[Cyclohexane-1,1'(3'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid
CAS No.	328233-46-1
Molecular Formula	C14H15NO4
Molecular Weight	261.27 g/mol
Synonyms	4-Carboxy-cis-3'-oxospiro[cyclohexane-1,1'(3'H)-furo[3,4-c]pyridine]; Spiro[cyclohexane-1,1'-[3H]furo[3,4-c]pyridine]-4-carboxylic acid, 3'-oxo-, cis-; (cis)-3'-Oxospiro[cyclohexane-1,1'(3'H)-furo[3,4-c]pyridine]-4-carboxylic acid; 328233-46-1; cis-3'-Oxospiro[cyclohexane-1,1'-[3H]furo[3,4-c]pyridine]-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our cis-3'-Oxo-Spiro[Cyclohexane-1,1'(3'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the material from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.