Description

trans-3'-Oxo-Spiro[Cyclohexane-1,1'(3'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and fused heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, offering a sophisticated scaffold for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Medicinal Chemistry Research: Used as a key scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Synthesis: Employed in the development and scale-up processes for new chemical entities (NCEs) requiring its specific fused spirocyclic core.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	trans-3'-Oxo-Spiro[Cyclohexane-1,1'(3'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid
CAS No.	328233-18-7
Molecular Formula	C14H15NO4
Molecular Weight	261.27 g/mol
Synonyms	trans-3'-Oxospiro[cyclohexane-1,1'(3'H)-furo[3,4-c]pyridine]-4-carboxylic acid; 4-Carboxy-3'-oxospiro[cyclohexane-1,1'(3'H)-furo[3,4-c]pyridine]; Spiro[cyclohexane-1,1'(3'H)-furo[3,4-c]pyridine]-4-carboxylic acid, 3'-oxo-, trans-; (4R)-3'-Oxospiro[cyclohexane-1,1'(3'H)-furo[3,4-c]pyridine]-4-carboxylic acid (enantiomer specific); Furo[3,4-c]pyridine-4-carboxylic acid, 1,1a,4,5-tetrahydro-3'H-spiro[cyclohexane-1,7'-]-, 3'-oxo-, trans-
EINECS	Contact for details

Quality Control

Our trans-3'-Oxo-Spiro[Cyclohexane-1,1'(3'H)-Furo[3,4-C]Pyridine]-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are designed to meet the stringent needs of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.