Description

trans-7'-Oxo-Spiro[Cyclohexane-1,5'(7'H)-Furo[3,4-B]Pyridine]-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and fused heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly for synthesizing novel drug candidates targeting complex biological pathways. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or metabolic disorder targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its unique three-dimensional scaffold.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial production of investigational new drugs.
• Biochemical Tool Compound: Potential use as a probe or inhibitor in biochemical assays to study specific enzyme or receptor functions.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	trans-7'-Oxo-Spiro[Cyclohexane-1,5'(7'H)-Furo[3,4-B]Pyridine]-4-Carboxylic Acid
CAS No.	328233-13-2
Molecular Formula	C14H15NO4
Molecular Weight	261.27 g/mol
Synonyms	7'-Oxospiro[cyclohexane-1,5'(7'H)-furo[3,4-b]pyridine]-4-carboxylic acid, trans-; (4R,7'R)-7'-Oxospiro[cyclohexane-1,5'(7'H)-furo[3,4-b]pyridine]-4-carboxylic acid; Spiro[furo[3,4-b]pyridine-5(7H),1'-cyclohexane]-4-carboxylic acid, 7'-oxo-; trans-7'-Oxospiro[cyclohexane-1,5'(7'H)-furo[3,4-b]pyridine]-4-carboxylic acid; CAS 328233-13-2; Furo[3,4-b]pyridine-4-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our trans-7'-Oxo-Spiro[Cyclohexane-1,5'(7'H)-Furo[3,4-B]Pyridine]-4-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the stringent requirements of pharmaceutical R&D and cGMP guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.