Description

Spiro[Isoindoline-1,4-Piperidin]-3-One Hcl is a high-purity spirocyclic organic compound with the CAS number 328233-04-1, serving as a critical building block in advanced pharmaceutical synthesis. This compound matters for its role as a sophisticated intermediate in the development of novel active pharmaceutical ingredients (APIs) targeting complex therapeutic areas. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the production of high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing complex molecular architectures in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the optimization and commercial-scale synthesis of target molecules for clinical trials and production.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral to the multi-step synthesis of final API molecules requiring the spiro[isoindoline-1,4-piperidin] core structure.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	Spiro[Isoindoline-1,4-Piperidin]-3-One Hcl
CAS No.	328233-04-1
Molecular Formula	C12H14N2O • HCl
Molecular Weight	238.71 g/mol
Synonyms	Spiro[isoindoline-1,4'-piperidin]-3-one hydrochloride; 3-Oxospiro[isoindoline-1,4'-piperidine] hydrochloride; 1',4'-Dihydrospiro[isoindoline-3,4'-piperidin]-1-one hydrochloride; 328233-04-1; Spiro(isoindoline-1,4-piperidin)-3-one HCl; Spirocyclic isoindolinone piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our Spiro[Isoindoline-1,4-Piperidin]-3-One Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.