Description

cis-1-Amino-Indan-2-Carboxylic Acid Ethyl Ester Hydrochloride is a high-purity chiral building block and synthetic intermediate of significant commercial importance. Its value lies in its rigid, fused-ring indane structure, which is crucial for imparting specific conformational properties in advanced pharmaceutical and agrochemical synthesis. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the creation of novel active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitor and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors and other biologically active molecules.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the indane scaffold provides structural rigidity.
• Peptidomimetics: Serves as a constrained amino acid analogue in the design of peptide-like drugs with enhanced metabolic stability.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective chemical transformations.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	cis-1-Amino-Indan-2-Carboxylic Acid Ethyl Ester Hydrochloride
CAS No.	327178-34-7
Molecular Formula	C12H16ClNO2
Molecular Weight	241.71 g/mol
Synonyms	(1S,2R)-1-Amino-2,3-dihydro-1H-indene-2-carboxylic acid ethyl ester hydrochloride; Ethyl (1S,2R)-1-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride; cis-1-Aminoindane-2-carboxylic acid ethyl ester HCl; (1S,2R)-AICA ethyl ester hydrochloride; cis-AICE hydrochloride; 1-Aminoindan-2-carboxylic acid ethyl ester, cis- isomer, hydrochloride; Ethyl 1-aminoindane-2-carboxylate hydrochloride (cis)
EINECS	Contact for details

Quality Control

Our cis-1-Amino-Indan-2-Carboxylic Acid Ethyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.