Description

3-Biphenyl-4'-Fluoro-Acetic Acid CAS NO 327107-49-3 is a high-purity fluorinated biphenyl acetic acid derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the unique combination of a biphenyl core and a fluorine substituent, which are key structural motifs for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas targeting inflammation, CNS disorders, and oncology, where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the biphenyl structure for target specificity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated organic electronic materials, where its rigid biphenyl structure contributes to desired mesogenic and electroluminescent properties.
• Organic Synthesis & Catalysis: Acts as a versatile synthon in cross-coupling reactions and as a ligand precursor in catalytic systems due to its functionalized aromatic rings.
• Life Science Research: Employed as a biochemical tool and probe in academic and industrial research to study enzyme interactions and receptor binding.
• Polymer Science: Can be incorporated as a monomer or additive to create specialty polymers with enhanced thermal stability and specific optical characteristics.

Basic Information

Product Name	3-Biphenyl-4'-Fluoro-Acetic Acid
CAS No.	327107-49-3
Molecular Formula	C14H11FO2
Molecular Weight	230.24 g/mol
Synonyms	4'-Fluoro-[1,1'-biphenyl]-3-acetic Acid; 3-(4'-Fluorobiphenyl-4-yl)acetic Acid; [1,1'-Biphenyl]-3-acetic Acid, 4'-Fluoro-; 4'-Fluoro-3-biphenylacetic Acid; 3-(4-Fluorophenyl)phenylacetic Acid; (3-Biphenyl-4'-yl)fluoroacetic Acid; Biphenyl-3-acetic Acid, 4'-Fluoro Derivative; FBPAA
EINECS	Contact for details

Quality Control

Every batch of 3-Biphenyl-4'-Fluoro-Acetic Acid is manufactured under a cGMP-compliant quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material typically meets a purity specification of ≥98.0% (by HPLC). A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0 %
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.