Description

tert-Butyl 6-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate is a protected heterocyclic amine derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its value lies in providing a versatile, reactive scaffold for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing the quinoline or tetrahydroquinoline core structures.
• Medicinal Chemistry Research: Used in the discovery and optimization of new chemical entities (NCEs) for various therapeutic targets.
• Process Chemistry Development: Employed in route scouting and scale-up studies for the commercial production of APIs.
• Fine Chemical Synthesis: Serves as a precursor for the preparation of specialty chemicals, agrochemicals, and advanced materials.
• Academic & Industrial R&D: A valuable reagent for synthetic methodology development and chemical biology studies in research laboratories.

Basic Information

Product Name	tert-Butyl 6-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	327044-56-4
Molecular Formula	C14H19NO3
Molecular Weight	249.31 g/mol
Synonyms	1-Boc-6-hydroxy-1,2,3,4-tetrahydroquinoline; 6-Hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 6-hydroxy-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1-N-Boc-6-hydroxy-1,2,3,4-tetrahydroquinoline; 6-Hydroxy-2,3-dihydro-1H-quinoline-1-carboxylic acid tert-butyl ester; Boc-6-OH-THQ; 327044-56-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Hydroxy-3,4-Dihydroquinoline-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.