Description

n-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide is a high-purity, advanced pharmaceutical intermediate characterized by its distinct heterocyclic and difluorinated aromatic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily sought by R&D chemists and process development teams in the global pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic categories.
• Agrochemical Research: Serves as a key scaffold for developing new generation pesticides and herbicides, leveraging the bioactivity of the chloropyridine and difluorobenzamide motifs.
• Ligand & Catalyst Development: Used in academic and industrial research to create specialized ligands for catalytic systems or as a model compound in methodological studies.
• Chemical Biology Probe Synthesis: Employed in the construction of molecular probes for studying enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or liquid crystals due to its rigid, conjugated structure.

Basic Information

Product Name	n-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide
CAS No.	325457-89-4
Molecular Formula	C12H7ClF2N2O
Molecular Weight	268.65 g/mol
Synonyms	3,4-Difluoro-N-(6-chloro-3-pyridinyl)benzamide; 6-Chloro-N-(3,4-difluorobenzoyl)nicotinamide; 325457-89-4; N-(6-Chloro-3-pyridinyl)-3,4-difluorobenzamide; Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-; 3,4-Difluoro-N-(6-chloropyridin-3-yl)benzamide
EINECS	Contact for details

Quality Control

Our n-(6-Chloropyridin-3-Yl)-3,4-Difluorobenzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.