Description

Fmoc-1,4-Diaminobutane Hydrochloride is a high-purity, protected diamine building block essential for solid-phase peptide synthesis (SPPS). This compound provides a critical, orthogonally protected amino group for the controlled elongation of peptide chains, ensuring high coupling efficiency and purity. It is primarily utilized by pharmaceutical R&D teams, CROs/CDMOs, and academic researchers developing novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for introducing a protected 1,4-diaminobutane (putrescine) moiety into peptide sequences.
• Linker and Spacer Chemistry: Used in the synthesis of peptide-drug conjugates (PDCs) and bioconjugates, where the diamine acts as a flexible spacer or attachment point.
• Synthesis of Polyamine Derivatives: A precursor for creating modified polyamine structures with potential biological activity.
• Biochemical Research: Employed in the study of polyamine metabolism and the development of enzyme inhibitors or molecular probes.
• Material Science: Can be used to functionalize surfaces or polymers by providing reactive amine groups after Fmoc deprotection.
• Combinatorial Chemistry: A valuable reagent in libraries for drug discovery targeting polyamine-utilizing pathways.

Basic Information

Product Name	Fmoc-1,4-Diaminobutane Hydrochloride
CAS No.	321660-77-9
Molecular Formula	C19H23ClN2O2
Molecular Weight	346.85 g/mol
Synonyms	N1-(9-Fluorenylmethoxycarbonyl)-1,4-butanediamine hydrochloride; Fmoc-Dab-OH? HCl; Fmoc-1,4-diaminobutane HCl; Nα-Fmoc-1,4-diaminobutane hydrochloride; 4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]butylamine hydrochloride; N-(9-Fluorenylmethoxycarbonyl)-1,4-diaminobutane hydrochloride; Fmoc-Putrescine hydrochloride; Fmoc-Dab(Boc)-OH? HCl (Note: This is a related, differentially protected form)
EINECS	Contact for details

Quality Control

Our Fmoc-1,4-Diaminobutane Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.