Description

(2R,3S)-2-Boc-Amino-3-Phenyl-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for research and development in pharmaceutical chemistry, particularly for creating active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, renin inhibitors, and other peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a specific stereocenter with a protected amine.
• Chemical Biology Research: Employed in the development of peptide probes, enzyme substrates, and inhibitors for biochemical studies.
• API Development: Serves as a building block for the research and scale-up manufacturing of new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.

Basic Information

Item	Detail
Product Name	(2R,3S)-2-Boc-Amino-3-Phenyl-Butyric Acid
CAS No.	321524-48-5
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	(2R,3S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylbutanoic acid; (2R,3S)-Boc-3-phenyl-D-isoasparagine; Boc-D-iso-Phe-OH; (2R,3S)-N-Boc-3-phenylbutyric acid; tert-Butyl (2R,3S)-2-amino-3-phenylbutanoate carboxylic acid; (2R,3S)-2-(Boc-amino)-3-phenylbutyric acid; N-Boc-(2R,3S)-3-phenylbutyric acid
EINECS	Contact for details

Quality Control

Our (2R,3S)-2-Boc-Amino-3-Phenyl-Butyric Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.