Description

1H-Pyrazol-5-Amine,1-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4-phenyl-(9Ci) is a high-value, structurally complex heterocyclic compound featuring a fused naphthyridine core with trifluoromethyl groups and a phenyl-substituted pyrazole amine. This compound matters as a sophisticated pharmaceutical intermediate and key building block for advanced organic synthesis, enabling the development of novel active molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating new drug candidates and functional chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential active pharmaceutical ingredients (APIs), particularly for targets in oncology, CNS, and anti-infective research.
• Agrochemical Research: Used as a building block for developing novel herbicides, fungicides, or insecticides, leveraging the biological activity of the naphthyridine and pyrazole motifs.
• Material Science: Acts as a monomer or functional additive in the development of advanced polymers, liquid crystals, or organic electronic materials due to its rigid, fluorinated structure.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, or labeled compounds for biochemical assays and diagnostic applications.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in heterocyclic chemistry, fluorination chemistry, and cross-coupling reactions.
• Custom Synthesis & Scale-up: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) supporting client projects from milligram to kilogram scale.

Basic Information

Item	Details
Product Name	1H-Pyrazol-5-Amine,1-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4-phenyl-(9Ci)
CAS No.	321522-20-7
Molecular Formula	C20H11F6N5
Molecular Weight	435.33 g/mol
Synonyms	1-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4-phenyl-1H-pyrazol-5-amine; 4-Phenyl-1-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-1H-pyrazol-5-amine; 1-(5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl)-4-phenyl-1H-pyrazol-5-amine; 321522-20-7; 1H-Pyrazol-5-amine, 1-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4-phenyl-; 1-(5,7-Bis(trifluoromethyl)naphthyridin-2-yl)-4-phenyl-1H-pyrazol-5-amine
EINECS	Contact for details

Quality Control

Our 1H-Pyrazol-5-Amine,1-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-4-phenyl-(9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), related substances, and residual solvents. Specifications can be aligned with cGMP standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%; Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.