Description

1-(3,4,5-Trifluorophenyl)Ethan-1-Amine Hydrochloride is a high-purity fluorinated aromatic amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a trifluoromethyl-substituted aniline moiety, which is instrumental for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the trifluorophenyl group enhances biological activity.
• Ligand & Catalyst Preparation: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Material Science Research: Building block for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Useful for synthesizing probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	1-(3,4,5-Trifluorophenyl)Ethan-1-Amine Hydrochloride
CAS No.	321318-35-8
Molecular Formula	C8H8ClF3N
Molecular Weight	217.60 g/mol
Synonyms	1-(3,4,5-Trifluorophenyl)ethanamine hydrochloride; α-Methyl-3,4,5-trifluorobenzylamine hydrochloride; 1-(3,4,5-Trifluorophenyl)ethylamine HCl; 3,4,5-Trifluoro-α-methylbenzylamine hydrochloride; (1-(3,4,5-Trifluorophenyl)ethyl)amine hydrochloride; 1-Aminoethyl-3,4,5-trifluorobenzene hydrochloride; 3,4,5-Trifluoroamphetamine hydrochloride (contextual); TFPEA·HCl
EINECS	Contact for details

Quality Control

Our 1-(3,4,5-Trifluorophenyl)Ethan-1-Amine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.