Description

1-(3,5-Difluorophenyl)Ethan-1-Amine Hydrochloride is a high-purity, fine chemical intermediate characterized by its difluorophenyl and amine hydrochloride functional groups. This compound is essential for the synthesis of advanced pharmaceutical molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas where fluorinated aromatic amines are key building blocks. It is primarily sought after by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially in CNS-active compounds and kinase inhibitors.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the difluorophenyl moiety contributes to biological activity and metabolic stability.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis within fine chemical production.
• Fluorinated Compound Libraries: A valuable reagent for medicinal chemistry teams creating focused libraries for high-throughput screening (HTS) in drug discovery.
• Material Science: Potential use as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced materials.
• Academic & Contract Research: Employed in fundamental organic chemistry research and by CROs (Contract Research Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1-(3,5-Difluorophenyl)Ethan-1-Amine Hydrochloride
CAS No.	321318-11-0
Molecular Formula	C8H9F2N·HCl
Molecular Weight	193.62 (Free base) / 230.08 (HCl salt)
Synonyms	1-(3,5-Difluorophenyl)ethanamine hydrochloride; α-Methyl-3,5-difluorobenzylamine hydrochloride; 1-(3,5-Difluorophenyl)ethylamine HCl; 3,5-Difluoro-α-methylbenzylamine hydrochloride; (1-(3,5-Difluorophenyl)ethyl)azanium chloride; 1-(3,5-Difluorophenyl)ethan-1-amine HCl
EINECS	Contact for details

Quality Control

Our 1-(3,5-Difluorophenyl)Ethan-1-Amine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.