Description

4-Chloro-7,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. This compound is valued for its unique molecular scaffold, which serves as a critical precursor in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel quinolone and fluoroquinolone derivatives.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel antibacterial and antiviral fluoroquinolone drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced fungicides and herbicides that leverage the quinolone core for enhanced activity.
• Material Science Research: Serves as a building block for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and specialty dyes.
• Chemical Biology Probes: Utilized in the synthesis of fluorescent tags and molecular probes for diagnostic and biochemical research applications.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects requiring functionalized quinoline derivatives.

Basic Information

Product Name	4-Chloro-7,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	318685-51-7
Molecular Formula	C₁₂H₈ClF₂NO₂
Molecular Weight	271.65 g/mol
Synonyms	Ethyl 4-Chloro-7,8-difluoroquinoline-3-carboxylate; 4-Chloro-7,8-difluoro-3-quinolinecarboxylic Acid Ethyl Ester; 318685-51-7; 4-Chloro-7,8-difluoroquinoline-3-ethyl carboxylate; 3-Quinolinecarboxylic acid, 4-chloro-7,8-difluoro-, ethyl ester; Ethyl 4-chloro-7,8-difluoro-3-quinolinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-Chloro-7,8-Difluoroquinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high standards, including cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.