Description

2-(4-Iodo-Phenyl)-Quinoline-4-Carboxylic Acid is a high-purity, functionalized quinoline derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular architecture, which combines a quinoline core with an iodophenyl substituent, making it a versatile intermediate for constructing complex molecules. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and as a precursor for metal-catalyzed cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in creating advanced active ingredients for crop protection products.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its conjugated quinoline system.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to form biaryl structures.
• Ligand Synthesis: Utilized in the preparation of complex chelating ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: Acts as a core structure for synthesizing fluorescent dyes and biological imaging agents.

Basic Information

Product Name	2-(4-Iodo-Phenyl)-Quinoline-4-Carboxylic Acid
CAS No.	312943-44-5
Molecular Formula	C16H10INO2
Molecular Weight	375.16 g/mol
Synonyms	4-Quinolinecarboxylic acid, 2-(4-iodophenyl)-; 2-(4-Iodophenyl)-4-quinolinecarboxylic acid; 2-(p-Iodophenyl)quinoline-4-carboxylic acid; 312943-44-5; Quinoline-4-carboxylic acid, 2-(4-iodophenyl)-; 2-(4-Iodophenyl)quinoline-4-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Iodo-Phenyl)-Quinoline-4-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.