Description

2-Amino-4-(4-Methoxyphenyl)-7,7-Dimethyl-5-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarbonitrile is a sophisticated, multifunctional heterocyclic compound that serves as a critical advanced pharmaceutical intermediate and key building block in modern organic synthesis. Its unique molecular architecture, featuring a quinoline core substituted with amino, cyano, and trifluoromethylphenyl groups, makes it invaluable for constructing complex molecules with targeted biological activity. This high-purity chemical is essential for research and development laboratories and production facilities in the pharmaceutical and agrochemical sectors, where it is used to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A pivotal building block for the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Serves as a key precursor in the development of new-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the quinoline scaffold.
• Organic Synthesis & Material Science: Used in academic and industrial R&D for constructing complex heterocyclic frameworks and exploring structure-activity relationships (SAR).
• Ligand & Catalyst Development: The amino and cyano functional groups make it a candidate for developing novel ligands in coordination chemistry and catalysis.
• Fluorinated Compound Synthesis: The presence of the trifluoromethyl group makes it a valuable synthon for introducing fluorine atoms into target molecules to enhance metabolic stability and lipophilicity.

Basic Information

Product Name	2-Amino-4-(4-Methoxyphenyl)-7,7-Dimethyl-5-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarbonitrile
CAS No.	311328-72-0
Molecular Formula	C26H24F3N3O2
Molecular Weight	467.48 g/mol
Synonyms	1,4,5,6,7,8-Hexahydro-2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1-[3-(trifluoromethyl)phenyl]-3-quinolinecarbonitrile; 3-Quinolinecarbonitrile, 1,4,5,6,7,8-hexahydro-2-amino-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1-[3-(trifluoromethyl)phenyl]-; 2-Amino-1,4,5,6,7,8-hexahydro-4-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-1-[3-(trifluoromethyl)phenyl]-3-quinolinecarbonitrile; CAS 311328-72-0; Hexahydroquinolinecarbonitrile derivative; Trifluoromethylphenyl-substituted quinolinecarbonitrile.
EINECS	Contact for details

Quality Control

Our production of 2-Amino-4-(4-Methoxyphenyl)-7,7-Dimethyl-5-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarbonitrile adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and reliable supply chain integrity makes us a trusted partner for critical intermediate sourcing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.