Description

2-Amino-4-(3,4-Dimethoxyphenyl)-7,7-Dimethyl-5-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex polycyclic structure incorporating a trifluoromethyl group. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by R&D laboratories and pharmaceutical manufacturers engaged in creating new therapeutic agents, where its specific molecular architecture enables the exploration of new chemical spaces and pharmacophores.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, or oncology.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization studies to establish structure-activity relationships (SAR) due to its modifiable quinoline and aminonitrile functionalities.
• Chemical Biology Probes: Employed in the development of chemical probes for studying enzyme function or protein-protein interactions in biological systems.
• Agrochemical Research: Potential application as an intermediate in the development of new active ingredients for crop protection, leveraging the stability imparted by the trifluoromethyl group.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in heterocyclic and fluorine chemistry.
• Contract Research and Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's outsourced discovery and development pipelines.

Basic Information

Product Name	2-Amino-4-(3,4-Dimethoxyphenyl)-7,7-Dimethyl-5-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarbonitrile
CAS No.	311328-69-5
Molecular Formula	C27H26F3N3O3
Molecular Weight	497.51 g/mol
Synonyms	1,4,5,6,7,8-Hexahydro-2-amino-4-(3,4-dimethoxyphenyl)-7,7-dimethyl-5-oxo-1-[3-(trifluoromethyl)phenyl]-3-quinolinecarbonitrile; 2-Amino-1,4,5,6,7,8-hexahydro-4-(3,4-dimethoxyphenyl)-7,7-dimethyl-5-oxo-1-[3-(trifluoromethyl)phenyl]-3-quinolinecarbonitrile; 3-Quinolinecarbonitrile, 2-amino-4-(3,4-dimethoxyphenyl)-1,4,5,6,7,8-hexahydro-7,7-dimethyl-5-oxo-1-[3-(trifluoromethyl)phenyl]-; CAS 311328-69-5
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-4-(3,4-Dimethoxyphenyl)-7,7-Dimethyl-5-Oxo-1-[3-(Trifluoromethyl)Phenyl]-1,4,5,6,7,8-Hexahydro-3-Quinolinecarbonitrile is manufactured and controlled under a strict quality management system. Our products undergo rigorous analytical testing to ensure high purity and consistent identity, meeting the exacting standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and spectroscopic data are available upon request for quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Single Maximum Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.