Description

4-[2-(Trifluoromethyl)Phenyl]-4H-1,2,4-Triazole-3-Thiol is a high-value heterocyclic compound featuring a trifluoromethylphenyl group and a thiol functional group. This unique structure makes it a critical building block and intermediate in advanced organic synthesis, particularly for applications requiring specific electronic and steric properties. It is primarily utilized by research institutions and industrial R&D departments focused on developing novel pharmaceuticals, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and plant growth regulators, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Acts as a ligand or a core unit in the design of metal-organic frameworks (MOFs), catalysts, and advanced polymers with tailored properties.
• Chemical Biology Probe Development: Utilized in creating molecular probes for studying enzyme inhibition and protein-ligand interactions due to its reactive thiol moiety.
• Organic Electronic Materials: Investigated as a component in the synthesis of organic semiconductors and charge-transport materials.

Basic Information

Product Name	4-[2-(Trifluoromethyl)Phenyl]-4H-1,2,4-Triazole-3-Thiol
CAS No.	306936-80-1
Molecular Formula	C9H6F3N3S
Molecular Weight	245.22 g/mol
Synonyms	4-(2-(Trifluoromethyl)phenyl)-4H-1,2,4-triazole-3-thiol; 4-(α,α,α-Trifluoro-o-tolyl)-1,2,4-triazole-3-thiol; 3-Mercapto-4-[2-(trifluoromethyl)phenyl]-1,2,4-triazole; 1,2,4-Triazole-3-thiol, 4-[2-(trifluoromethyl)phenyl]-; 4-(2-Trifluoromethylphenyl)-1,2,4-triazole-3-thiol; 306936-80-1; 4-(2-Trifluoromethylphenyl)-4H-1,2,4-triazole-3-thiol
EINECS	Contact for details

Quality Control

Our 4-[2-(Trifluoromethyl)Phenyl]-4H-1,2,4-Triazole-3-Thiol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.