Description

8,9-Difluoro-5-Methyl-1,7-Dioxo-6,7-Dihydro-1H,5H-Pyrido[3,2,1-Ij]Quinoline-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of next-generation antibacterial agents. It is primarily sought after by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development of complex, high-value therapeutic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel fluoroquinolone and quinolone-based antibacterial agents.
• Organic Synthesis Building Block: Used in research and development for constructing complex polycyclic molecular frameworks with potential biological activity.
• Chemical Research: Serves as a reference standard and a starting material for medicinal chemistry programs targeting DNA gyrase and topoisomerase IV inhibition.
• Fine Chemical Production: Employed in the multi-step synthesis of specialized, high-value compounds for the life sciences industry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	8,9-Difluoro-5-Methyl-1,7-Dioxo-6,7-Dihydro-1H,5H-Pyrido[3,2,1-Ij]Quinoline-2-Carboxylic Acid
CAS No.	306935-69-3
Molecular Formula	C₁₇H₁₁F₂NO₄
Molecular Weight	331.27 g/mol
Synonyms	8,9-Difluoro-5-methyl-1,7-dioxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid; 8,9-Difluoro-5-methyl-1,7-dioxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid; 306935-69-3; Pyrido[3,2,1-ij]quinoline-2-carboxylic acid, 8,9-difluoro-5-methyl-1,7-dioxo-6,7-dihydro-1H,5H-; Difluoro-methyl-dioxo-dihydro-pyridoquinoline-carboxylic acid
EINECS	Contact for details

Quality Control

Our 8,9-Difluoro-5-Methyl-1,7-Dioxo-6,7-Dihydro-1H,5H-Pyrido[3,2,1-Ij]Quinoline-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to ensure full traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.