Description

4-Chloro-8-(trifluoromethoxy)-2-(trifluoromethyl)quinoline is a high-value, multi-fluorinated quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring both chloro and trifluoromethoxy/trifluoromethyl substituents, makes it an essential building block for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty chemicals, such as ligands for catalysis or monomers for advanced polymers with specific electronic properties.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tagging agent in probe development for studying biological systems and protein functions.
• Organic Light-Emitting Diodes (OLEDs): Investigated as a potential electron-transport or host material in the fabrication of OLED devices due to its fluorinated aromatic system.

Basic Information

Product Name	4-Chloro-8-(trifluoromethoxy)-2-(trifluoromethyl)quinoline
CAS No.	306935-27-3
Molecular Formula	C₁₁H₄ClF₆NO
Molecular Weight	315.60 g/mol
Synonyms	4-Chloro-8-(trifluoromethoxy)-2-(trifluoromethyl)quinoline; 2-(Trifluoromethyl)-4-chloro-8-(trifluoromethoxy)quinoline; 4-Chloro-2-trifluoromethyl-8-trifluoromethoxyquinoline; Quinoline, 4-chloro-8-(trifluoromethoxy)-2-(trifluoromethyl)-; 8-(Trifluoromethoxy)-4-chloro-2-(trifluoromethyl)quinoline; CAS 306935-27-3
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-8-(trifluoromethoxy)-2-(trifluoromethyl)quinoline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.