Description

8-(Trifluoromethoxy)-2-(Trifluoromethyl)Quinolin-4-Ol is a high-value, fluorinated quinoline derivative that serves as a critical advanced pharmaceutical intermediate and organic synthesis building block. Its unique molecular structure, featuring both trifluoromethoxy and trifluoromethyl substituents, imparts desirable properties such as enhanced metabolic stability and lipophilicity for target molecules. This compound is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the fluorine motifs improve biological activity and environmental persistence.
• Material Science: Serves as a precursor for functional organic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized in creating fluorinated probes and tags for studying biological mechanisms and diagnostics.
• Organic Synthesis: A versatile scaffold for constructing complex heterocyclic compounds in academic and industrial research.
• Fluorine Chemistry: An important reagent for introducing multiple fluorine-containing groups into target molecules in a single step.

Basic Information

Product Name	8-(Trifluoromethoxy)-2-(Trifluoromethyl)Quinolin-4-Ol
CAS No.	306935-26-2
Molecular Formula	C12H5F6NO2
Molecular Weight	309.17 g/mol
Synonyms	4-Hydroxy-8-(trifluoromethoxy)-2-(trifluoromethyl)quinoline; 8-(Trifluoromethoxy)-2-(trifluoromethyl)-4-quinolinol; 2-Trifluoromethyl-8-trifluoromethoxy-quinolin-4-ol; 4-Quinolinol, 8-(trifluoromethoxy)-2-(trifluoromethyl)-; Quinolin-4-ol, 8-(trifluoromethoxy)-2-(trifluoromethyl)-; TMFQ-OH; 8-TFMO-2-TFM-4-ol-Quinoline
EINECS	Contact for details

Quality Control

Our production of 8-(Trifluoromethoxy)-2-(trifluoromethyl)quinolin-4-ol adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, impurity profile, and physical characteristics. Our quality system is designed to support cGMP and ISO standards for reliable use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.