Description

(+)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane(Cyclooctadiene)Rhodium (I) Tetrafluoroborate is a highly specialized, chiral organometallic catalyst belonging to the DuPhos ligand family. Its value lies in enabling highly enantioselective hydrogenation and other asymmetric transformations critical for synthesizing single-isomer pharmaceutical intermediates and fine chemicals. This catalyst is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, enamides, and ketones to produce chiral building blocks with high enantiomeric excess (ee).
• Pharmaceutical Intermediate Synthesis: Critical for the production of optically pure active pharmaceutical ingredients (APIs), including β-amino acids, unnatural amino acids, and other complex chiral molecules.
• Agrochemical Synthesis: Used in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Enables the synthesis of specialty chemicals, flavors, and fragrances where specific chirality is required for functionality.
• Methodology Development & Scale-Up: Employed in process chemistry R&D for developing and optimizing scalable, cost-effective catalytic routes.
• Academic & Industrial Research: A valuable tool for exploring new asymmetric catalytic reactions and mechanistic studies in organometallic chemistry.

Basic Information

Item	Details
Product Name	(+)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane(Cyclooctadiene)Rhodium (I) Tetrafluoroborate
CAS No.	305818-67-1
Molecular Formula	C22H40BF4P2Rh
Molecular Weight	556.20 g/mol
Synonyms	(R,R)-Me-DuPhos Rhodium (I) Tetrafluoroborate COD Complex; [(R,R)-Me-DuPhos)Rh(COD)]BF4; (R,R)-1,2-Bis(2,5-dimethylphospholano)ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (R,R)-Me-DuPhos-Rh(COD)BF4; DuPhos Rhodium Catalyst; Rh-(R,R)-Me-DuPhos(COD)BF4; Asymmetric Hydrogenation Catalyst Rh-MeDuPhos; (2R,2'R,5R,5'R)-1,1'-(1,2-ethanediyl)bis2,5-dimethylphospholanerhodium tetrafluoroborate
EINECS	Contact for details

Quality Control

Every batch of our (+)-1,2-Bis((2R,5R)-2,5-Dimethylphospholano)Ethane(Cyclooctadiene)Rhodium (I) Tetrafluoroborate is produced and tested under strict quality management protocols to ensure consistent high performance and purity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as Rhodium content, enantiomeric purity of the ligand, and solvent residues. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Rhodium Content	~18.5% (Theoretical)
Solvent Residues (NMR/GC)	Meets internal specifications
Moisture Content (KF)	< 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.