Description

4-(4-Aminobenzyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is a key pharmaceutical intermediate featuring a protected piperazine ring and a primary aniline functional group, enabling versatile downstream chemical modifications. This compound is critical for medicinal chemists in the research and development of novel therapeutic agents, particularly for its role as a building block in small molecule drug candidates. It is primarily utilized by R&D laboratories and contract manufacturing organizations (CMOs) in the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs) for central nervous system (CNS) and oncology drug candidates.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors, leveraging its piperazine core for molecular recognition.
• Kinase Inhibitor Development: Acts as a scaffold for creating novel kinase inhibitors, a major class of targeted cancer therapies.
• GPCR Ligand Research: Employed in the design and synthesis of ligands for G-protein-coupled receptors (GPCRs) due to its structural flexibility.
• Peptidomimetic Chemistry: Provides a rigid, nitrogen-containing heterocycle for constructing peptidomimetics and conformationally constrained analogs.
• Chemical Library Production: A valuable starting material for generating diverse compound libraries in high-throughput screening campaigns for drug discovery.

Basic Information

Product Name	4-(4-Aminobenzyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	304897-49-2
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	1-Boc-4-(4-aminobenzyl)piperazine; tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate; 4-(4-Aminobenzyl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl 4-[(4-aminophenyl)methyl]-1-piperazinecarboxylate; 4-(4-Aminobenzyl)piperazine-1-carboxylic Acid tert-Butyl Ester; N-Boc-4-(4-aminobenzyl)piperazine; 304897-49-2; 4-(4-Aminobenzyl)-1-Boc-piperazine
EINECS	Contact for details

Quality Control

Our 4-(4-Aminobenzyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.