Description

N1-Ethyl-4-Trifluoromethanesulfonyl-Benzene-1,2-Diamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethanesulfonyl (triflyl) and diamine functional groups. This compound is essential for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel small-molecule therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry, especially for projects requiring the introduction of fluorine-containing motifs to modulate pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the trifluoromethanesulfonyl group contributes to biological activity and environmental stability.
• Material Science: Serves as a precursor for specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Employed as a versatile reagent in organic synthesis for introducing protected diamine and electron-withdrawing sulfonyl groups.
• Fluorine Chemistry: A valuable substrate for further fluorination reactions and the creation of complex fluorinated molecular architectures.

Basic Information

Product Name	N1-Ethyl-4-Trifluoromethanesulfonyl-Benzene-1,2-Diamine
CAS No.	304646-59-1
Molecular Formula	C9H11F3N2O2S
Molecular Weight	268.26 g/mol
Synonyms	4-(Ethylamino)-3-nitrobenzenesulfonyl fluoride (precursor); 1-Ethyl-4-(trifluoromethanesulfonyl)benzene-1,2-diamine; N-Ethyl-4-(triflyl)-1,2-benzenediamine; 4-(Trifluoromethanesulfonyl)-N-ethyl-1,2-phenylenediamine; 1,2-Benzenediamine, N1-ethyl-4-(trifluoromethylsulfonyl)-; 304646-59-1; N1-Ethyl-4-triflyl-o-phenylenediamine
EINECS	Contact for details

Quality Control

Our N1-Ethyl-4-Trifluoromethanesulfonyl-Benzene-1,2-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.