Description

1,4-Dioxa-8-Azaspiro[4.5]Decane,8-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-(9Ci) is a sophisticated heterocyclic organic compound featuring a unique spirocyclic and naphthyridine architecture, functionalized with trifluoromethyl groups. This complex structure makes it a high-value advanced intermediate or building block for pharmaceutical research and fine chemical synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecules with targeted properties.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, or infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, where the naphthyridine core and fluorine atoms can contribute to biological activity and environmental stability.
• Ligand & Catalyst Development: The nitrogen-rich heterocyclic structure makes it a potential precursor for creating novel ligands used in catalytic systems for asymmetric synthesis.
• Material Science: May be employed in the synthesis of organic electronic materials, such as components for OLEDs or semiconductors, due to its rigid, conjugated system.
• Fluorinated Compound Libraries: An essential substrate for generating diverse fluorinated compound libraries for high-throughput screening in drug discovery programs.
• Chemical Biology Probes: Used to develop molecular probes for studying enzyme function or biological pathways, leveraging its distinctive structural motif.

Basic Information

Product Name	1,4-Dioxa-8-Azaspiro[4.5]Decane,8-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-(9Ci)
CAS No.	303151-61-3
Molecular Formula	C₁₉H₁₇F₆N₃O₂
Molecular Weight	433.35 g/mol
Synonyms	8-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane; 1,4-Dioxa-8-azaspiro[4.5]decane, 8-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-; 8-(5,7-Bis(trifluoromethyl)naphthyridin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane; 303151-61-3; 1,4-Dioxa-8-azaspiro[4.5]decane,8-[5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-(9CI); Spirocyclic naphthyridine derivative; Naphthyridine-spiroketal intermediate
EINECS	Contact for details

Quality Control

Every batch of 1,4-Dioxa-8-Azaspiro[4.5]Decane,8-[5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-yl]-(9Ci) is produced and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support development and commercial projects with custom purity grades and scalable synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Standard Grade)
Purity (HPLC)	≥ 98% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.