Description

2-(Methylsulfanyl)-3-Phenyl-5,6-Dihydro-4(3H)-Oxospiro(Benzo[H]Quinazoline-5,1'-Cyclopentane) is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic quinazoline structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially those targeting central nervous system disorders and oncology.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly those with quinazoline-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities (NCEs).
• API Development: Serves as a building block in the development of Active Pharmaceutical Ingredients (APIs) for experimental therapies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-(Methylsulfanyl)-3-Phenyl-5,6-Dihydro-4(3H)-Oxospiro(Benzo[H]Quinazoline-5,1'-Cyclopentane)
CAS No.	301352-38-5
Molecular Formula	C24H22N2OS
Molecular Weight	386.51 g/mol
Synonyms	2-(Methylthio)-3-phenyl-5,6-dihydro-4(3H)-oxospiro[benzo[h]quinazoline-5,1'-cyclopentane]; Spiro[cyclopentane-1,5'-[5,6]dihydrobenzo[h]quinazolin]-4'(3'H)-one, 2'-(methylthio)-3'-phenyl-; 2-Methylsulfanyl-3-phenyl-3,5,6,10b-tetrahydro-4H-spiro[cyclopentane-1,8'-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin]-4-one; 301352-38-5; 2-(Methylsulfanyl)-3-phenyl-5,6-dihydro-4H-spiro[benzo[h]quinazoline-5,1'-cyclopentane]-4-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.