Description

2-(Ethylsulfanyl)-4-Oxo-3-Phenyl-3,4,5,6-Tetrahydrobenzo[H]Quinazoline-5-Spiro-1'-Cyclopentane is a sophisticated spiro-fused heterocyclic compound that serves as a high-value synthetic intermediate and building block. Its unique molecular architecture, featuring a quinazoline core fused with a spiro-cyclopentane ring, makes it a critical precursor for advanced research and development in medicinal chemistry. This compound is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers for the synthesis of novel bioactive molecules and complex chemical libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and high-throughput screening libraries to explore new therapeutic pathways.
• Organic Synthesis Reagent: Serves as a versatile scaffold for constructing complex polycyclic frameworks in academic and industrial research settings.
• Chemical Biology Probe: Potential use in developing molecular probes to study enzyme function or protein-ligand interactions due to its distinctive spirocyclic structure.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals and advanced materials requiring specific heterocyclic motifs.

Basic Information

Product Name	2-(Ethylsulfanyl)-4-Oxo-3-Phenyl-3,4,5,6-Tetrahydrobenzo[H]Quinazoline-5-Spiro-1'-Cyclopentane
CAS No.	301352-36-3
Molecular Formula	C23H22N2OS
Molecular Weight	374.50 g/mol
Synonyms	2-(Ethylthio)-4-oxo-3-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-5-spiro-1'-cyclopentane; 3,4,5,6-Tetrahydro-2-(ethylthio)-4-oxo-3-phenylbenzo[h]quinazoline-5-spiro-1'-cyclopentane; 5-Spirocyclopentane-2-(ethylsulfanyl)-3-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazolin-4-one; 301352-36-3; Benzo[h]quinazoline spirocyclopentane derivative; Spiro[cyclopentane-1,5'-[5,6]dihydrobenzo[h]quinazolin]-4'(3'H)-one, 2'-(ethylthio)-3'-phenyl-
EINECS	Contact for details

Quality Control

Our 2-(Ethylsulfanyl)-4-Oxo-3-Phenyl-3,4,5,6-Tetrahydrobenzo[H]Quinazoline-5-Spiro-1'-Cyclopentane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.