Description

(1,3-Bis-(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene)Dichloro(o-Isopropoxyphenylmethylene)Ruthenium is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst, renowned for its exceptional thermal stability and functional group tolerance. This advanced organometallic compound is critical for enabling efficient and selective carbon-carbon double bond formation in complex molecular architectures. It is an indispensable tool for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, where precision and reliability in synthetic methodology are paramount.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP) steps in the production of active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Development: Facilitating the synthesis of novel herbicides, fungicides, and insecticides with unique macrocyclic or olefinic structures.
• Advanced Polymer & Material Science: Serving as a catalyst for ROMP to create specialized polymers, functionalized surfaces, and smart materials with tailored properties.
• Fine Chemical & Specialty Chemical Manufacturing: Used in the synthesis of flavors, fragrances, and other high-value, structurally complex organic molecules.
• Academic & Industrial R&D: A staple catalyst in research laboratories for methodology development, total synthesis projects, and exploring new chemical space.
• Process Chemistry Optimization: Valued for its robustness and longer catalyst lifetime, making it suitable for scaling up metathesis reactions from lab to pilot plant.

Basic Information

Product Name	(1,3-Bis-(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene)Dichloro(o-Isopropoxyphenylmethylene)Ruthenium
CAS No.	301224-40-8
Molecular Formula	C₃₁H₄₂Cl₂N₂ORu
Molecular Weight	626.65 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation; Hoveyda-Grubbs Catalyst II; (H₂IMes)(Cl)₂Ru=CH(2-iPrO-C₆H₄); Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](2-isopropoxyphenylmethylene)ruthenium; HG II; Zhan Catalyst 1B; RuCl₂(H₂IMes)(CH-2-(iPrO)-C₆H₄); CAS 301224-40-8
EINECS	Contact for details

Quality Control

Every batch of our (1,3-Bis-(2,4,6-Trimethylphenyl)-2-Imidazolidinylidene)Dichloro(o-Isopropoxyphenylmethylene)Ruthenium is manufactured and handled under a strict quality management system. We guarantee high catalytic activity and lot-to-lot consistency through comprehensive analytical testing, including NMR, HPLC, and elemental analysis. A detailed Certificate of Analysis (COA) specifying purity, identity, and performance-related parameters is provided with each shipment to ensure it meets your rigorous research and production standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97%
Elemental Analysis (C, H, N)	Within theoretical range
Catalytic Activity	Benchmarked via standard RCM test reaction

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.