Description

(S)-tert-Butoxycarbonylamino-Pyridin-3-Yl-Acetic Acid CAS NO 300372-37-6 is a high-purity chiral building block and protected amino acid derivative essential for advanced organic synthesis. Its primary value lies in serving as a key intermediate for constructing complex molecules with defined stereochemistry, crucial for pharmaceutical research and development. This compound is particularly needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in oncology, neurology, and antiviral research.
• Peptidomimetics & Peptide Synthesis: Used to incorporate a pyridylalanine analog into peptide chains, modifying their biological activity, stability, and binding properties.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing the efficiency of stereoselective reactions.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Acts as a building block for developing new chiral active ingredients with improved efficacy and environmental profiles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical purity.

Basic Information

Item	Details
Product Name	(S)-tert-Butoxycarbonylamino-Pyridin-3-Yl-Acetic Acid
CAS No.	300372-37-6
Molecular Formula	C₁₃H₁₈N₂O₄
Molecular Weight	266.29 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-2-(pyridin-3-yl)acetic acid; (S)-Boc-3-pyridylglycine; (S)-N-Boc-3-pyridylglycine; (S)-2-(Boc-amino)-2-(3-pyridyl)acetic acid; Boc-L-3-Pyridylglycine; (S)-2-(tert-Butoxycarbonylamino)-2-(3-pyridyl)acetic acid; (S)-N-(tert-Butoxycarbonyl)-3-pyridylglycine; (S)-α-((tert-Butoxycarbonyl)amino)-3-pyridineacetic acid
EINECS	Contact for details

Quality Control

Our (S)-tert-Butoxycarbonylamino-Pyridin-3-Yl-Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chiral purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.