Description

5,6,7,8-Tetrahydro-Pyrido[4,3-D]Pyrimidine-2,4-Diamine Hydrochloride is a high-purity pharmaceutical intermediate and heterocyclic building block. This compound is valued for its role as a critical synthon in the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially kinase inhibitors.
• Biochemical Research: Used as a reference standard or reagent in pharmacological and biological studies.
• Organic Synthesis: Serves as a versatile precursor for constructing fused pyrimidine and pyridine ring systems in medicinal chemistry.
• Process Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP production.

Basic Information

Product Name	5,6,7,8-Tetrahydro-Pyrido[4,3-D]Pyrimidine-2,4-Diamine Hydrochloride
CAS No.	39949-17-2
Molecular Formula	C7H12N6·HCl
Molecular Weight	216.67 g/mol
Synonyms	5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine hydrochloride; 2,4-Diamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride; Pyrido[4,3-d]pyrimidine-2,4-diamine, 5,6,7,8-tetrahydro-, hydrochloride; 39949-17-2; UNII-8K9V5S2D1F; 8K9V5S2D1F; SCHEMBL218022; BDBM50111271
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-Pyrido[4,3-D]Pyrimidine-2,4-Diamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.